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High-throughput screening of mutations affecting SARS-CoV-2 spike functions.
Xia, Shuai; Liu, Zezhong; Jiang, Shibo.
Affiliation
  • Xia S; Key Laboratory of Medical Molecular Virology, Ministry of Education (MOE)/National Health Commission (NHC)/Chinese Academy of Medical Sciences (CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China.
  • Liu Z; Key Laboratory of Medical Molecular Virology, Ministry of Education (MOE)/National Health Commission (NHC)/Chinese Academy of Medical Sciences (CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China.
  • Jiang S; Key Laboratory of Medical Molecular Virology, Ministry of Education (MOE)/National Health Commission (NHC)/Chinese Academy of Medical Sciences (CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, School of Pharmacy, Shanghai Medical College, Fudan University, Shanghai 200032, China. Electronic address: shibojiang@fudan.edu.cn.
Trends Immunol ; 44(5): 321-323, 2023 05.
Article in En | MEDLINE | ID: mdl-37031063
ABSTRACT
The spike (S) protein of SARS-CoV-2, which is undergoing rapid evolution, plays crucial roles in viral immune escape, infectivity, and transmissibility. To gain clinical insight, Dadonaite et al. developed a novel deep mutational scanning (DMS) platform for mapping the effects of S protein mutations on immune evasion and viral infectivity.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: High-Throughput Screening Assays / COVID-19 Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Journal: Trends Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2023 Document type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: High-Throughput Screening Assays / COVID-19 Type of study: Diagnostic_studies / Screening_studies Limits: Humans Language: En Journal: Trends Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2023 Document type: Article Affiliation country: China