Title: Serious COVID-19 may have a causal relationship with myocardial injury: A Mendelian randomization study.
Front Genet
; 14: 1135887, 2023.
Article
in En
| MEDLINE
| ID: mdl-37035726
ABSTRACT
Background:
The association of coronavirus disease 2019 (COVID-19) with myocardial injury is not well known. This study explored the association between them using the Mendelian randomization (MR) method.Method:
We obtained summary data from genome-wide association studies (GWAS) on myocardial injury and COVID-19 from public databases. Then, as tool variables, we chose single nucleotide polymorphisms associated with susceptibility and COVID-19 severity to investigate the causal relationship of COVID-19 with myocardial injury using inverse-variance weighting (IVW) as the primary approach. Finally, the reliability of the results was evaluated by performing sensitivity analyses.Results:
As revealed by the IVW analyses, the seriously hospitalized patients with COVID-19 had causality with myocardial injury, with an ß of 0.14 and 95% confidence interval (CI) of 0.03-0.25 (p = 0.01). The results showed that COVID-19 with severe respiratory symptoms positively affected myocardial injury (ß = 0.11, 95% CI = 0.03-0.19; p = 0.005).Conclusion:
According to this study, severe respiratory symptoms and hospitalization due to COVID-19 may increase the risk of myocardial injury.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Type of study:
Clinical_trials
Language:
En
Journal:
Front Genet
Year:
2023
Document type:
Article
Affiliation country:
China