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Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors.
El-Kalyoubi, Samar; El-Sebaey, Samiha A; Rashad, A M; Al-Ghulikah, Hanan A; Ghorab, Mostafa M; Elfeky, Sherin M.
Affiliation
  • El-Kalyoubi S; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
  • El-Sebaey SA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
  • Rashad AM; Accelerator and Ion Sources Department, Nuclear Research Center, Atomic Energy Authority, Cairo, Egypt.
  • Al-Ghulikah HA; Central Lab for Elemental and Isotopic Analysis, NRC, Atomic Energy Authority, Cairo, Egypt.
  • Ghorab MM; Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
  • Elfeky SM; Department of Drug Radiation Research, National Centre for Radiation Research and Technology (NCRRT), Egyptian Atomic Energy Authority (EAEA), Cairo, Egypt.
J Enzyme Inhib Med Chem ; 38(1): 2198163, 2023 Dec.
Article in En | MEDLINE | ID: mdl-37036011

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / HSP90 Heat-Shock Proteins / Topoisomerase II Inhibitors / Antineoplastic Agents Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2023 Document type: Article Affiliation country: Egypt Country of publication: United kingdom

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / HSP90 Heat-Shock Proteins / Topoisomerase II Inhibitors / Antineoplastic Agents Limits: Humans Language: En Journal: J Enzyme Inhib Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2023 Document type: Article Affiliation country: Egypt Country of publication: United kingdom