Ecdysone signaling determines lateral polarity and remodels neurites to form Drosophila's left-right brain asymmetry.
Cell Rep
; 42(4): 112337, 2023 04 25.
Article
in En
| MEDLINE
| ID: mdl-37044096
ABSTRACT
Left-right (LR) asymmetry of the brain is fundamental to its higher-order functions. The Drosophila brain's asymmetrical body (AB) consists of a structural pair arborized from AB neurons and is larger on the right side than the left. We find that the AB initially forms LR symmetrically and then develops LR asymmetrically by neurite remodeling that is specific to the left AB and is dynamin dependent. Additionally, neuronal ecdysone signaling inhibition randomizes AB laterality, suggesting that ecdysone signaling determines AB's LR polarity. Given that AB's LR asymmetry relates to memory formation, our research establishes AB as a valuable model for studying LR asymmetry and higher-order brain function relationships.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neurites
/
Ecdysone
Type of study:
Clinical_trials
Limits:
Animals
Language:
En
Journal:
Cell Rep
Year:
2023
Document type:
Article
Affiliation country:
Japan