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Bromodomain inhibitor i-BET858 triggers a unique transcriptional response coupled to enhanced DNA damage, cell cycle arrest and apoptosis in high-grade ovarian carcinoma cells.
Quintela, Marcos; James, David W; Pociute, Agne; Powell, Lydia; Edwards, Kadie; Coombes, Zoe; Garcia, Jetzabel; Garton, Neil; Das, Nagindra; Lutchman-Singh, Kerryn; Margarit, Lavinia; Beynon, Amy L; Rioja, Inmaculada; Prinjha, Rab K; Harker, Nicola R; Gonzalez, Deyarina; Conlan, R Steven; Francis, Lewis W.
Affiliation
  • Quintela M; Swansea University Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
  • James DW; Swansea University Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
  • Pociute A; Swansea University Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
  • Powell L; Swansea University Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
  • Edwards K; Swansea University Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
  • Coombes Z; Swansea University Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
  • Garcia J; Swansea University Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
  • Garton N; Immunology Research Unit, GlaxoSmithKline, Medicines Research Centre, Stevenage, SG1 2NY, UK.
  • Das N; Swansea Bay University Health Board, Swansea, SA12 7BR, UK.
  • Lutchman-Singh K; Swansea Bay University Health Board, Swansea, SA12 7BR, UK.
  • Margarit L; Swansea University Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
  • Beynon AL; Cwm Taf Morgannwg University Health Board, Swansea, SA2 8QA, UK.
  • Rioja I; Porvair Sciences Ltd, Wrexham, LL13 9XS, UK.
  • Prinjha RK; Immunology Research Unit, GlaxoSmithKline, Medicines Research Centre, Stevenage, SG1 2NY, UK.
  • Harker NR; Immunology Research Unit, GlaxoSmithKline, Medicines Research Centre, Stevenage, SG1 2NY, UK.
  • Gonzalez D; Immunology Research Unit, GlaxoSmithKline, Medicines Research Centre, Stevenage, SG1 2NY, UK.
  • Conlan RS; Swansea University Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
  • Francis LW; Swansea University Medical School, Swansea University, Singleton Park, Swansea, SA2 8PP, UK.
Clin Epigenetics ; 15(1): 63, 2023 04 15.
Article in En | MEDLINE | ID: mdl-37060086
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Carcinoma / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Clin Epigenetics Year: 2023 Document type: Article Affiliation country: United kingdom
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ovarian Neoplasms / Carcinoma / Antineoplastic Agents Limits: Female / Humans Language: En Journal: Clin Epigenetics Year: 2023 Document type: Article Affiliation country: United kingdom