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Pomiferin targets SERCA, mTOR, and P-gp to induce autophagic cell death in apoptosis-resistant cancer cells, and reverses the MDR phenotype in cisplatin-resistant tumors in vivo.
Qu, Yuan-Qing; Song, Lin-Lin; Xu, Su-Wei; Yu, Margaret Sum Yee; Kadioglu, Onat; Michelangeli, Francesco; Law, Betty Yuen Kwan; Efferth, Thomas; Lam, Christopher Wai-Kei; Wong, Vincent Kam Wai.
Affiliation
  • Qu YQ; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau; Faculty of Medicine, Macau University of Science and Technology, Macau.
  • Song LL; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau.
  • Xu SW; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau; Department of Basic Medicine of Zhuhai Health School, Zhuhai, China.
  • Yu MSY; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau.
  • Kadioglu O; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany.
  • Michelangeli F; Department of Biological Sciences, University of Chester, Chester, UK.
  • Law BYK; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau.
  • Efferth T; Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Staudinger Weg 5, Mainz 55128, Germany.
  • Lam CW; Faculty of Medicine, Macau University of Science and Technology, Macau. Electronic address: wklam@must.edu.mo.
  • Wong VKW; Dr. Neher's Biophysics Laboratory for Innovative Drug Discovery, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau. Electronic address: kawwong@must.edu.mo.
Pharmacol Res ; 191: 106769, 2023 05.
Article in En | MEDLINE | ID: mdl-37061145
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagic Cell Death / Lung Neoplasms / Antineoplastic Agents Limits: Animals Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: Macao
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagic Cell Death / Lung Neoplasms / Antineoplastic Agents Limits: Animals Language: En Journal: Pharmacol Res Journal subject: FARMACOLOGIA Year: 2023 Document type: Article Affiliation country: Macao