A case of thymoma-associated myasthenia gravis accompanied with myositis showing the clusters of histiocyte along the fascicles in perimysium.
Clin Neurol Neurosurg
; 229: 107715, 2023 06.
Article
in En
| MEDLINE
| ID: mdl-37068437
ABSTRACT
Patients with myasthenia gravis (MG) often have other autoimmune disorders. However, the coexistence of MG and myositis is rare. Here, we report a case of a 77-year-old woman who developed mild fatigable muscle weakness and diplopia in 3 months. Serum creatine kinase was elevated to 1385 IU/L. Antibodies to acetylcholine receptor (AChR), titin and voltage-gated potassium channel 1.4 (Kv 1.4) were all positive while all tested myositis-specific autoantibodies were negative. Standard needle electromyography showed fibrillation potential and early recruitment of motor units. The repetitive nerve stimulations were consistent with a disorder of the neuromuscular junction. Muscle biopsy showed that the clusters of histiocyte were present along the fascicles in perimysium and some of them invaded into endomysium.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Thymoma
/
Thymus Neoplasms
/
Myasthenia Gravis
/
Myositis
Type of study:
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
Clin Neurol Neurosurg
Year:
2023
Document type:
Article
Affiliation country:
Japan