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Effects of dietary fibers or probiotics on functional constipation symptoms and roles of gut microbiota: a double-blinded randomized placebo trial.
Lai, Hao; Li, Yunfeng; He, Yafang; Chen, Fangyao; Mi, Baibing; Li, Junqi; Xie, Jiawen; Ma, Guoqing; Yang, Jinzhao; Xu, Kun; Liao, Xia; Yin, Yan; Liang, Junrong; Kong, Liyun; Wang, Xinyan; Li, Zhongxia; Shen, Yuan; Dang, Shaonong; Zhang, Lei; Wu, Qian; Zeng, Lingxia; Shi, Lin; Zhang, Xuguang; Tian, Tian; Liu, Xin.
Affiliation
  • Lai H; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Li Y; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • He Y; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Chen F; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Mi B; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Li J; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Xie J; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Ma G; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Yang J; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Xu K; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Liao X; Department of Nutrition, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
  • Yin Y; Department of Gastroenterology, The First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.
  • Liang J; Department of Gastroenterology, Tangdu Hospital, Fourth Military Medical University, Xi'an, China.
  • Kong L; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Wang X; BYHEALTH Institute of Nutrition & Health, Guangzhou, China.
  • Li Z; BYHEALTH Institute of Nutrition & Health, Guangzhou, China.
  • Shen Y; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Dang S; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Zhang L; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Wu Q; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Zeng L; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
  • Shi L; School of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an, China.
  • Zhang X; BYHEALTH Institute of Nutrition & Health, Guangzhou, China.
  • Tian T; Department of Nutrition, Xi'an Daxing Hospital, Xi'an, China.
  • Liu X; Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, School of Public Health, Global Health Institute, Health Science Center, Xi'an Jiaotong University, Xi'an, China.
Gut Microbes ; 15(1): 2197837, 2023.
Article in En | MEDLINE | ID: mdl-37078654
What is the context?Supplementation of dietary fibers, such as psyllium husk or wheat bran (10 ~ 15 g/day) may relieve constipation symptoms, but bloating and flatulence are major concerns on a high fiber intake.Functional constipation patients had alternated gut microbiota profiles, while meta-analysis suggested that multispecies probiotics may increase bowel movement frequency and relieve hard stool in functional constipation.Dietary fibers or probiotics may lead to before-after changes of gut microbiota in patients with functional constipation, but time-series continued changes of gut microbiota during the intervention are unknown.Elevation of 5-hydroxytryptamine synthesis in enterochromaffin cells may affect bowel movement. And the elevated plasma 5-hydroxytryptamine was observed in functional constipation patients.What is new? Daily supplement of three prebiotic formulas with dietary fibers (polydextrose, psyllium husk, wheat bran, together with oligosaccharides), or a probiotic formula with Bifidobacterium animalis subsp. lactis HN019 + Lacticaseibacillus rhamnosus HN001 effectively relieved hard stool in functional constipation patients after 4 weeks intervention.We identified continued increasing or decreasing gut microbial genera over the intervention. Dietary fiber ­ gut microbiota (Anaerostipes)­constipation relieve (bowel movement frequency) evidence axis was identified in this human trial.Probiotic supplementation marginally reduced plasma 5-hydroxytryptamine, possibly associated with changes in BMF-related gut microbial genera.Intervention-specific baseline gut microbiota well predicted the responsiveness of constipation symptom relief.What is the impact? We provided references for the dosage and duration of dietary fiber/probiotics recommendations for adults with functional constipation, and advanced the microbial genera evidences of the fibers/probiotics-microbiota-laxation theory in humans.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psyllium / Probiotics / Gastrointestinal Microbiome / Bifidobacterium animalis / Gastrointestinal Diseases Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies Limits: Adult / Humans Language: En Journal: Gut Microbes Year: 2023 Document type: Article Affiliation country: China Country of publication: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Psyllium / Probiotics / Gastrointestinal Microbiome / Bifidobacterium animalis / Gastrointestinal Diseases Type of study: Clinical_trials / Diagnostic_studies / Prognostic_studies Limits: Adult / Humans Language: En Journal: Gut Microbes Year: 2023 Document type: Article Affiliation country: China Country of publication: United States