The role of the Nrf2/GSH antioxidant system in cisplatin resistance in malignant rhabdoid tumours.

Hannon Barroeta, Patricia; O'Sullivan, Maureen J; Zisterer, Daniela M

Hannon Barroeta, Patricia; O'Sullivan, Maureen J; Zisterer, Daniela M.

Affiliation

Hannon Barroeta P; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Pearse St, Dublin, D02 R590, Ireland. hannonbp@tcd.ie.
O'Sullivan MJ; The National Children's Research Centre, Children's Health Ireland at Crumlin, Dublin, D12 N512, Ireland.
Zisterer DM; School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Pearse St, Dublin, D02 R590, Ireland.

J Cancer Res Clin Oncol ; 149(11): 8379-8391, 2023 Sep.

Article in En | MEDLINE | ID: mdl-37079050

Subject(s)

Cisplatin; Rhabdoid Tumor; Humans; Child; Cisplatin/pharmacology; Antioxidants/pharmacology; Rhabdoid Tumor/drug therapy; NF-E2-Related Factor 2/metabolism; Reactive Oxygen Species/metabolism; Glutathione/metabolism; Buthionine Sulfoximine; Apoptosis; Cell Line, Tumor

Key words

Apoptosis; Chemoresistance; Glutathione; Malignant rhabdoid tumour; Nuclear erythroid-related factor-2; Reactive oxygen species

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cisplatin / Rhabdoid Tumor Type of study: Prognostic_studies Limits: Child / Humans Language: En Journal: J Cancer Res Clin Oncol Year: 2023 Document type: Article Affiliation country: Ireland Country of publication: Germany

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