Effects of Very Low- and High-Frequency Subthalamic Stimulation on Motor Cortical Oscillations During Rhythmic Lower-Limb Movements in Parkinson's Disease Patients.
J Parkinsons Dis
; 13(4): 549-561, 2023.
Article
in En
| MEDLINE
| ID: mdl-37092236
ABSTRACT
BACKGROUND:
Standard high-frequency deep brain stimulation (HF-DBS) at the subthalamic nucleus (STN) is less effective for lower-limb motor dysfunctions in Parkinson's disease (PD) patients. However, the effects of very low frequency (VLF; 4âHz)-DBS on lower-limb movement and motor cortical oscillations have not been compared.OBJECTIVE:
To compare the effects of VLF-DBS and HF-DBS at the STN on a lower-limb pedaling motor task and motor cortical oscillations in patients with PD and with and without freezing of gait (FOG).METHODS:
Thirteen PD patients with bilateral STN-DBS performed a cue-triggered lower-limb pedaling motor task with electroencephalography (EEG) in OFF-DBS, VLF-DBS (4âHz), and HF-DBS (120-175âHz) states. We performed spectral analysis on the preparatory signals and compared GO-cue-triggered theta and movement-related beta oscillations over motor cortical regions across DBS conditions in PD patients and subgroups (PDFOG-and PDFOG+).RESULTS:
Both VLF-DBS and HF-DBS decreased the linear speed of the pedaling task in PD, and HF-DBS decreased speed in both PDFOG-and PDFOG+. Preparatory theta and beta activities were increased with both stimulation frequencies. Both DBS frequencies increased motor cortical theta activity during pedaling movement in PD patients, but this increase was only observed in the PDFOGâ+âgroup. Beta activity was not significantly different from OFF-DBS at either frequency regardless of FOG status.CONCLUSION:
Results suggest that VL and HF DBS may induce similar effects on lower-limb kinematics by impairing movement speed and modulating motor cortical oscillations in the lower frequency band.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Subthalamic Nucleus
/
Gait Disorders, Neurologic
/
Deep Brain Stimulation
Limits:
Humans
Language:
En
Journal:
J Parkinsons Dis
Year:
2023
Document type:
Article
Affiliation country:
United States