Interleukin 10, but not tumor necrosis factor-alpha, gene variations are associated with factor VII inhibitor development.
Lab Med
; 55(1): 8-12, 2024 Jan 06.
Article
in En
| MEDLINE
| ID: mdl-37094795
ABSTRACT
OBJECTIVE:
Development of alloantibodies against coagulation factor VII (FVII) is the main therapeutic challenge in severe congenital FVII deficiency. About 7% of patients with severe congenital FVII deficiency develop an inhibitor against FVII. In this research, the relationship between interleukin (IL)-10 and tumor necrosis factor-alpha (TNF)-α gene variants and inhibitor development was evaluated for a group of Iranian patients with severe congenital factor VII deficiency.METHODS:
Patients with FVII deficiency were divided into 2 groups 6 cases and 15 controls. Genotyping was performed using the amplification-refractory mutation system polymerase chain reaction.RESULTS:
We found that IL-10 rs1800896 A>G gene variant is associated with the risk of FVII inhibitor development (OR = 0.077, 95% CI = 0.016-0.380, P = .001), whereas the TNFα-rs1800629G>A variant has no relation with inhibitor development in severe FVII deficiency.CONCLUSION:
The results show that the IL-10 rs1800896 A>G variant increases the risk of developing an inhibitor in patients with severe congenital FVII deficiency.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Factor VII
/
Tumor Necrosis Factor-alpha
Type of study:
Risk_factors_studies
Limits:
Humans
Country/Region as subject:
Asia
Language:
En
Journal:
Lab Med
Year:
2024
Document type:
Article
Affiliation country:
Iran