Proton therapy and/or helical tomotherapy for locally advanced sinonasal skull base adenoid cystic carcinoma: Focus on experience of the Institut Curie and review of literature.
Head Neck
; 45(7): 1619-1631, 2023 07.
Article
in En
| MEDLINE
| ID: mdl-37097003
ABSTRACT
BACKGROUND:
Sinonasal adenoid cystic carcinomas (SNACC) have high propensity for skull base (SB) infiltration. Unresectability or incomplete surgical resection in such cases make radiotherapy treatment paramount. Curative dose escalation is challenging because of adjacent organs at risk, especially in locally advanced cases.METHODS:
Eighteen patients that had locally advanced SB SNACC with unresectable or incomplete surgical resection treated by proton therapy and/or helical tomotherapy at Institut Curie between 3/2010 and 8/2020 were retrospectively included.RESULTS:
After median follow-up of 52 months, 5-year OS, LRRFS, DMFS, DFS rates were, respectively, 47% (95%CI 26-83), 50% (95%CI 36-88), 39% (95%CI 26-81), 33% (95%CI 22-73). One patient had grade 4 late optic nerve disorder. Eight patients had grade 3 late toxicity including mainly hearing impairments.CONCLUSION:
Proton therapy and helical tomotherapy are effective and safe methods for curative dose escalation of locally advanced SB SNACC, which are a poor prognosis subgroup. Available literature suggests carbon-ion therapy could be an efficient alternative.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Paranasal Sinus Neoplasms
/
Carcinoma
/
Carcinoma, Adenoid Cystic
/
Radiotherapy, Intensity-Modulated
/
Proton Therapy
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Head Neck
Journal subject:
NEOPLASIAS
Year:
2023
Document type:
Article
Affiliation country:
France