Disulfidptosis: a new target for metabolic cancer therapy.
J Exp Clin Cancer Res
; 42(1): 103, 2023 Apr 27.
Article
in En
| MEDLINE
| ID: mdl-37101248
ABSTRACT
Altered metabolism is a hallmark of cancer and presents a vulnerability that can be exploited in cancer treatment. Regulated cell death (RCD) plays a crucial role in cancer metabolic therapy. A recent study has identified a new metabolic-related RCD known as disulfidptosis. Preclinical findings suggest that metabolic therapy using glucose transporter (GLUT) inhibitors can trigger disulfidptosis and inhibit cancer growth. In this review, we summarize the specific mechanisms underlying disulfidptosis and outline potential future research directions. We also discuss the challenges that may arise in the clinical translation of disulfidptosis research.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cell Death
/
Neoplasms
Type of study:
Prognostic_studies
Limits:
Humans
Language:
En
Journal:
J Exp Clin Cancer Res
Year:
2023
Document type:
Article
Affiliation country:
China