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Social connections and risk of incident mild cognitive impairment, dementia, and mortality in 13 longitudinal cohort studies of ageing.
Mahalingam, Gowsaly; Samtani, Suraj; Lam, Ben Chun Pan; Lipnicki, Darren M; Lima-Costa, Maria Fernanda; Blay, Sergio Luis; Castro-Costa, Erico; Shifu, Xiao; Guerchet, Maëlenn; Preux, Pierre-Marie; Gbessemehlan, Antoine; Skoog, Ingmar; Najar, Jenna; Sterner, Therese Rydberg; Scarmeas, Nikolaos; Yannakoulia, Mary; Dardiotis, Themis; Kim, Ki-Woong; Riedel-Heller, Steffi; Röhr, Susanne; Pabst, Alexander; Shahar, Suzana; Numbers, Katya; Ganguli, Mary; Hughes, Tiffany F; Chang, Chung-Chou H; Crowe, Michael; Ng, Tze Pin; Gwee, Xinyi; Chua, Denise Qian Ling; Rymaszewska, Joanna; Wolf-Ostermann, Karin; Welmer, Anna-Karin; Stafford, Jean; Mélis, René; Vernooij-Dassen, Myrra; Jeon, Yun-Hee; Sachdev, Perminder S; Brodaty, Henry.
Affiliation
  • Mahalingam G; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine and Health, UNSW Sydney, Australia.
  • Samtani S; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine and Health, UNSW Sydney, Australia.
  • Lam BCP; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine and Health, UNSW Sydney, Australia.
  • Lipnicki DM; School of Psychology and Public Health, La Trobe University Melbourne, UNSW Sydney, Australia.
  • Lima-Costa MF; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine and Health, UNSW Sydney, Australia.
  • Blay SL; Center for Studies in Public Health and Aging' René Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.
  • Castro-Costa E; Department of Psychiatry, Federal University of Sao Paulo, Sao Paulo, São Paulo, Brazil.
  • Shifu X; Center for Studies in Public Health and Aging' René Rachou Research Center, Oswaldo Cruz Foundation, Belo Horizonte, Minas Gerais, Brazil.
  • Guerchet M; Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
  • Preux PM; Inserm U1094, IRD UMR270, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.
  • Gbessemehlan A; Inserm U1094, IRD UMR270, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.
  • Skoog I; Inserm U1094, IRD UMR270, Univ. Limoges, CHU Limoges, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, Limoges, France.
  • Najar J; Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP), at the University of Gothenburg, Mölndal, Sweden.
  • Sterner TR; Region Västra Götaland, Psychiatry, Cognition and Old Age Psychiatry Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Scarmeas N; Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP), at the University of Gothenburg, Mölndal, Sweden.
  • Yannakoulia M; Region Västra Götaland, Psychiatry, Cognition and Old Age Psychiatry Clinic, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Dardiotis T; Department of Psychiatry and Neurochemistry, Neuropsychiatric Epidemiology Unit, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, Centre for Ageing and Health (AGECAP), at the University of Gothenburg, Mölndal, Sweden.
  • Kim KW; 1st Department of Neurology, Aiginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
  • Riedel-Heller S; Taub Institute for Research in Alzheimer's Disease and the Aging Brain, The Gertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, New York, USA.
  • Röhr S; Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
  • Pabst A; Department of Neurology, University of Thessaly, Larisa, Greece.
  • Shahar S; Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.
  • Numbers K; Department of Psychiatry, Seoul National University College of Medicine, Seoul, South Korea.
  • Ganguli M; Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, South Korea.
  • Hughes TF; Institute of Social Medicine, Occupational Health and Public Health (ISAP), Faculty of Medicine, University of Leipzig, Leipzig, Germany.
  • Chang CH; Institute of Social Medicine, Occupational Health and Public Health (ISAP), Faculty of Medicine, University of Leipzig, Leipzig, Germany.
  • Crowe M; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
  • Ng TP; Health and Ageing Research Team, School of Psychology, Massey University, Palmerston, New Zealand.
  • Gwee X; Institute of Social Medicine, Occupational Health and Public Health (ISAP), Faculty of Medicine, University of Leipzig, Leipzig, Germany.
  • Chua DQL; Centre for Healthy Aging and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
  • Rymaszewska J; Centre for Healthy Brain Ageing (CHeBA), Discipline of Psychiatry and Mental Health, Faculty of Medicine and Health, UNSW Sydney, Australia.
  • Wolf-Ostermann K; Departments of Psychiatry, Epidemiology, and Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Welmer AK; Youngstown State University, Youngstown, Ohio, USA.
  • Stafford J; Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
  • Mélis R; Department of Psychology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Vernooij-Dassen M; Yong Loo Lin School of Medicine, Department of Psychological Medicine, National University of Singapore, Singapore, Singapore.
  • Jeon YH; Yong Loo Lin School of Medicine, Department of Psychological Medicine, National University of Singapore, Singapore, Singapore.
  • Sachdev PS; Yong Loo Lin School of Medicine, Department of Psychological Medicine, National University of Singapore, Singapore, Singapore.
  • Brodaty H; Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland.
Alzheimers Dement ; 19(11): 5114-5128, 2023 11.
Article in En | MEDLINE | ID: mdl-37102417
ABSTRACT

INTRODUCTION:

Previous meta-analyses have linked social connections and mild cognitive impairment, dementia, and mortality. However, these used aggregate data from North America and Europe and examined a limited number of social connection markers.

METHODS:

We used individual participant data (N = 39271, Mage  = 70.67 (40-102), 58.86% female, Meducation  = 8.43 years, Mfollow-up  = 3.22 years) from 13 longitudinal ageing studies. A two-stage meta-analysis of Cox regression models examined the association between social connection markers with our primary outcomes.

RESULTS:

We found associations between good social connections structure and quality and lower risk of incident mild cognitive impairment (MCI); between social structure and function and lower risk of incident dementia and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.

DISCUSSION:

Different aspects of social connections - structure, function, and quality - are associated with benefits for healthy aging internationally. HIGHLIGHTS Social connection structure (being married/in a relationship, weekly community group engagement, weekly family/friend interactions) and quality (never lonely) were associated with lower risk of incident MCI. Social connection structure (monthly/weekly friend/family interactions) and function (having a confidante) were associated with lower risk of incident dementia. Social connection structure (living with others, yearly/monthly/weekly community group engagement) and function (having a confidante) were associated with lower risk of mortality. Evidence from 13 longitudinal cohort studies of ageing indicates that social connections are important targets for reducing risk of incident MCI, incident dementia, and mortality. Only in Asian cohorts, being married/in a relationship was associated with reduced risk of dementia, and having a confidante was associated with reduced risk of dementia and mortality.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dementia / Cognitive Dysfunction Type of study: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limits: Aged / Female / Humans / Male Language: En Journal: Alzheimers Dement Year: 2023 Document type: Article Affiliation country: Australia
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dementia / Cognitive Dysfunction Type of study: Etiology_studies / Observational_studies / Risk_factors_studies / Systematic_reviews Limits: Aged / Female / Humans / Male Language: En Journal: Alzheimers Dement Year: 2023 Document type: Article Affiliation country: Australia