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Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6.
Van Horn, Kurt S; Wang, Dongju; Medina-Cleghorn, Daniel; Lee, Peter S; Bryant, Clifford; Altobelli, Chad; Jaishankar, Priyadarshini; Leung, Kevin K; Ng, Raymond A; Ambrose, Andrew J; Tang, Yinyan; Arkin, Michelle R; Renslo, Adam R.
Affiliation
  • Van Horn KS; Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States.
  • Wang D; Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States.
  • Medina-Cleghorn D; School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China.
  • Lee PS; Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States.
  • Bryant C; Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States.
  • Altobelli C; Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States.
  • Jaishankar P; Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States.
  • Leung KK; Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States.
  • Ng RA; Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States.
  • Ambrose AJ; Chempartner Corporation, 280 Utah Avenue, South San Francisco, California 94080, United States.
  • Tang Y; Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States.
  • Arkin MR; Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States.
  • Renslo AR; Department of Pharmaceutical Chemistry, University of California, San Francisco, 600 16th Street, San Francisco, California 94143, United States.
J Am Chem Soc ; 145(18): 10015-10021, 2023 05 10.
Article in En | MEDLINE | ID: mdl-37104712
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Caspases / Cysteine Limits: Humans Language: En Journal: J Am Chem Soc Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Caspases / Cysteine Limits: Humans Language: En Journal: J Am Chem Soc Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States