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Staphylococcal biofilm: penetration and bioavailability of vancomycin with or without rifampin.
Daffinee, Kathryn E; O'Neill, Emily T; Bleick, Callan R; Williams, Geoff; Antoci, Valentin; Garcia, Dioscaris; LaPlante, Kerry L.
Affiliation
  • Daffinee KE; Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI, USA.
  • O'Neill ET; Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI, USA; College of Pharmacy, University of Rhode Island, Kingston, RI, USA.
  • Bleick CR; College of Pharmacy, University of Rhode Island, Kingston, RI, USA.
  • Williams G; Leduc Bioimaging Facility, Brown University, Division of Biology and Medicine, Providence, RI, USA.
  • Antoci V; Department of Orthopaedics, The Warren Alpert School of Medicine, Brown University, Providence, RI, USA; The Diane N. Weiss Center for Orthopaedic Trauma Research, Rhode Island Hospital, Providence, RI, USA.
  • Garcia D; Department of Orthopaedics, The Warren Alpert School of Medicine, Brown University, Providence, RI, USA; The Diane N. Weiss Center for Orthopaedic Trauma Research, Rhode Island Hospital, Providence, RI, USA.
  • LaPlante KL; Infectious Diseases Research Program, Providence Veterans Affairs Medical Center, Providence, RI, USA; College of Pharmacy, University of Rhode Island, Kingston, RI, USA; Warren Alpert Medical School of Brown University, Division of Infectious Diseases, Providence, RI, USA. Electronic address: Kerry
Diagn Microbiol Infect Dis ; 106(3): 115947, 2023 Jul.
Article in En | MEDLINE | ID: mdl-37116243
ABSTRACT
We measured antibiotic penetration and bioavailability in staphylococcus biofilms using simulated humanized concentrations of fluorescent vancomycin plus or minus rifampin. Vancomycin percent recovery across biofilm layers wasupper = 46%, middle = 40%, and lower = 33%. Vancomycin plus rifampin was not significantly different (P = 0.65). Addition of rifampin did not improve vancomycin penetration across biofilm layers.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Vancomycin Limits: Humans Language: En Journal: Diagn Microbiol Infect Dis Year: 2023 Document type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcal Infections / Vancomycin Limits: Humans Language: En Journal: Diagn Microbiol Infect Dis Year: 2023 Document type: Article Affiliation country: United States