Miniaturizing chemistry and biology using droplets in open systems.
Nat Rev Chem
; 7(6): 439-455, 2023 06.
Article
in En
| MEDLINE
| ID: mdl-37117816
ABSTRACT
Open droplet microfluidic systems manipulate droplets on the picolitre-to-microlitre scale in an open environment. They combine the compartmentalization and control offered by traditional droplet-based microfluidics with the accessibility and ease-of-use of open microfluidics, bringing unique advantages to applications such as combinatorial reactions, droplet analysis and cell culture. Open systems provide direct access to droplets and allow on-demand droplet manipulation within the system without needing pumps or tubes, which makes the systems accessible to biologists without sophisticated setups. Furthermore, these systems can be produced with simple manufacturing and assembly steps that allow for manufacturing at scale and the translation of the method into clinical research. This Review introduces the different types of open droplet microfluidic system, presents the physical concepts leveraged by these systems and highlights key applications.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biology
/
Microfluidics
Language:
En
Journal:
Nat Rev Chem
Year:
2023
Document type:
Article
Affiliation country:
United States