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Ferroptosis in diabetic nephropathy: Mechanisms and therapeutic implications.
Mengstie, Misganaw Asmamaw; Seid, Mohammed Abdu; Gebeyehu, Natnael Atnafu; Adella, Getachew Asmare; Kassie, Gizchew Ambaw; Bayih, Wubet Alebachew; Gesese, Molalegn Mesele; Anley, Denekew Tenaw; Feleke, Sefineh Fenta; Zemene, Melkamu Aderajew; Dessie, Anteneh Mengist; Solomon, Yenealem; Bantie, Berihun; Dejenie, Tadesse Asmamaw; Teshome, Assefa Agegnehu; Abebe, Endeshaw Chekol.
Affiliation
  • Mengstie MA; Department of Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
  • Seid MA; Department of Physiology, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
  • Gebeyehu NA; Department of Midwifery, College of Medicine and Health Science, Wolaita Sodo University, Sodo, Ethiopia.
  • Adella GA; Department of Reproductive Health and Nutrition, School of Public Health, Woliata Sodo University, Sodo, Ethiopia.
  • Kassie GA; Department of Epidemiology and Biostatistics, School of Public Health, Woliata Sodo University, Sodo, Ethiopia.
  • Bayih WA; Department of Epidemiology and preventive Medicine, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Australia.
  • Gesese MM; Department of Midwifery, College of Medicine and Health Science, Wolaita Sodo University, Sodo, Ethiopia.
  • Anley DT; Department of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
  • Feleke SF; Department of Public Health, College of Health Sciences, Woldia University, Woldia, Ethiopia.
  • Zemene MA; Department of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
  • Dessie AM; Department of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
  • Solomon Y; Department of Medical Laboratory Science, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
  • Bantie B; Department of Comprehensive Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
  • Dejenie TA; Department of Medical Biochemistry, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
  • Teshome AA; Department of Anatomy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
  • Abebe EC; Department of Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia.
Metabol Open ; 18: 100243, 2023 Jun.
Article in En | MEDLINE | ID: mdl-37124126
ABSTRACT
Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apoptotic, regulated cell death, characterized by the buildup of intracellular lipid peroxides to lethal levels. Although the role of programmed cell deaths like apoptosis, autophagy, and necroptosis in the pathogenesis of DN has been demonstrated, the implication of ferroptosis in DN was least interrogated. Hence, the main aim of this review was to discuss the current understanding of ferroptosis focusing on its potential mechanisms, its involvement in DN, and emerging therapeutic opportunities.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Metabol Open Year: 2023 Document type: Article Affiliation country: Ethiopia
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Metabol Open Year: 2023 Document type: Article Affiliation country: Ethiopia