Mesenchymal stromal cells regulate THP-1-differentiated macrophage cytokine production by activating Akt/mammalian target of rapamycin complex 1 pathway.

Ko, Jung Hwa; Oh, Joo Youn

Ko, Jung Hwa; Oh, Joo Youn.

Affiliation

Ko JH; Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital, Jongno-gu, Seoul, Korea.
Oh JY; Laboratory of Ocular Regenerative Medicine and Immunology, Biomedical Research Institute, Seoul National University Hospital, Jongno-gu, Seoul, Korea; Department of Ophthalmology, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea. Electronic address: bonzoo1@snu.ac.kr.

Cytotherapy ; 25(8): 858-865, 2023 08.

Article in En | MEDLINE | ID: mdl-37125989

Subject(s)

Mesenchymal Stem Cells; Proto-Oncogene Proteins c-akt; Humans; Proto-Oncogene Proteins c-akt/metabolism; Cyclooxygenase 2/metabolism; TOR Serine-Threonine Kinases/metabolism; TOR Serine-Threonine Kinases/pharmacology; Mechanistic Target of Rapamycin Complex 1/metabolism; Mechanistic Target of Rapamycin Complex 1/pharmacology; Macrophages/metabolism

Key words

Akt; THP-1; cyclooxygenase-2; mTORC1; macrophage; mammalian target of rapamycin; mesenchymal stromal cell

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proto-Oncogene Proteins c-akt / Mesenchymal Stem Cells Limits: Humans Language: En Journal: Cytotherapy Journal subject: TERAPEUTICA Year: 2023 Document type: Article

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