Cutaneous Malignant Melanoma With Rhabdomyosarcomatous Dedifferentiation: an Immunohistological and Molecular Case Study With Literature Review.
Am J Dermatopathol
; 45(7): 470-474, 2023 Jul 01.
Article
in En
| MEDLINE
| ID: mdl-37130217
ABSTRACT
ABSTRACT Cutaneous malignant melanoma can show a wide range of cytomorphological variability, in particular exhibiting a rhabdoid appearance is not uncommon in melanoma cells; however, the phenomenon of "dedifferentiation" with loss of melanocytic immunohistochemical properties and expression of skeletal muscle immunomarkers is exceedingly rare. Owing to the rarity of such melanomas, their clinicopathological features and molecular profile remain largely unknown. In this report, we describe the clinical, immunomorphological, and molecular features of melanomas with rhabdomyosarcomatous dedifferentiation by presenting a new case and exploring the literature for the previously reported cases.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rhabdomyosarcoma
/
Skin Neoplasms
/
Melanoma
Limits:
Humans
Language:
En
Journal:
Am J Dermatopathol
Year:
2023
Document type:
Article
Affiliation country:
Australia