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Orthogonal dual reporter-based gain-of-signal assay for probing SARS-CoV-2 3CL protease activity in living cells: inhibitor identification and mutation investigation.
Bei, Zhu-Chun; Yu, Huanhuan; Wang, Hong; Li, Qingyun; Wang, Baogang; Zhang, Dongna; Xu, Likun; Zhao, Liangliang; Dong, Shuwei; Song, Yabin.
Affiliation
  • Bei ZC; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.
  • Yu H; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.
  • Wang H; The Affiliated AnNing First Hospital, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, People's Republic of China.
  • Li Q; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.
  • Wang B; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.
  • Zhang D; Clinical Laboratory, Chinese People's Liberation Army, Taiyuan, People's Republic of China.
  • Xu L; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.
  • Zhao L; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.
  • Dong S; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.
  • Song Y; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China.
Emerg Microbes Infect ; 12(1): 2211688, 2023 Dec.
Article in En | MEDLINE | ID: mdl-37144395
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Emerg Microbes Infect Year: 2023 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Emerg Microbes Infect Year: 2023 Document type: Article Country of publication: United States