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The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma.
Luo, George; Aldridge, Kristin; Chen, Toby; Aslot, Vivek; Kim, Byung-Gyu; Han, Eun Hyang; Singh, Neelima; Li, Sai; Xiao, Tsan Sam; Sporn, Michael B; Letterio, John J.
Affiliation
  • Luo G; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Aldridge K; Triterpenoid Therapeutics Inc., Tunbridge, VT, USA.
  • Chen T; Trinity College of Arts and Sciences, Duke University, Durham, NC, USA.
  • Aslot V; Department of Chemical and Biomolecular Engineering, Case Western Reserve University, Cleveland, OH, USA.
  • Kim BG; The Angie Fowler Adolescent and Young Adult Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.
  • Han EH; The Case Comprehensive Cancer Center, Cleveland, OH, USA.
  • Singh N; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
  • Li S; The Angie Fowler Adolescent and Young Adult Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.
  • Xiao TS; The Case Comprehensive Cancer Center, Cleveland, OH, USA.
  • Sporn MB; Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
  • Letterio JJ; The Angie Fowler Adolescent and Young Adult Cancer Institute, University Hospitals Rainbow Babies & Children's Hospital, Cleveland, OH, USA.
Mol Oncol ; 17(12): 2526-2545, 2023 Dec.
Article in En | MEDLINE | ID: mdl-37149844
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multiple Myeloma Limits: Animals / Humans Language: En Journal: Mol Oncol Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multiple Myeloma Limits: Animals / Humans Language: En Journal: Mol Oncol Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States