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Exploration of imatinib and nilotinib-derived templates as the P2-Ligand for HIV-1 protease inhibitors: Design, synthesis, protein X-ray structural studies, and biological evaluation.
Ghosh, Arun K; Mishevich, Jennifer L; Kovela, Satish; Shaktah, Ryan; Ghosh, Ajay K; Johnson, Megan; Wang, Yuan-Fang; Wong-Sam, Andres; Agniswamy, Johnson; Amano, Masayuki; Takamatsu, Yuki; Hattori, Shin-Ichiro; Weber, Irene T; Mitsuya, Hiroaki.
Affiliation
  • Ghosh AK; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN, 47907, United States. Electronic address: akghosh@purdue.edu.
  • Mishevich JL; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN, 47907, United States.
  • Kovela S; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN, 47907, United States.
  • Shaktah R; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN, 47907, United States.
  • Ghosh AK; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN, 47907, United States.
  • Johnson M; Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN, 47907, United States.
  • Wang YF; Department of Biology, Georgia State University, Atlanta, GA, 30303, United States.
  • Wong-Sam A; Department of Biology, Georgia State University, Atlanta, GA, 30303, United States.
  • Agniswamy J; Department of Biology, Georgia State University, Atlanta, GA, 30303, United States.
  • Amano M; Departments of Infectious Diseases and Hematology, Kumamoto University Graduate School of Biomedical Sciences, Kumamoto, 860-8556, Japan.
  • Takamatsu Y; Refractory Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, 162-8655, Japan.
  • Hattori SI; Refractory Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, 162-8655, Japan.
  • Weber IT; Department of Biology, Georgia State University, Atlanta, GA, 30303, United States.
  • Mitsuya H; Departments of Infectious Diseases and Hematology, Kumamoto University Graduate School of Biomedical Sciences, Kumamoto, 860-8556, Japan; Refractory Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo, 162-8655, Japan; Experimental Retrovirology Section, HIV and
Eur J Med Chem ; 255: 115385, 2023 Jul 05.
Article in En | MEDLINE | ID: mdl-37150084
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / HIV Protease Inhibitors Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HIV-1 / HIV Protease Inhibitors Language: En Journal: Eur J Med Chem Year: 2023 Document type: Article