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Intrauterine desensitization enables long term survival of human oligodendrocyte progenitor cells without immunosuppression.
Ye, Dou; Qu, Suqing; Yang, Yinxiang; Wang, Zhaoyan; Wang, Qian; Liu, Weipeng; Zhang, Fan; Guan, Qian; Wang, Xiaohua; Zang, Jing; Li, Xin; Liu, Hengtao; Yao, Ruiqin; Feng, Zhichun; Luan, Zuo.
Affiliation
  • Ye D; Department of Pediatrics, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100037, China.
  • Qu S; Medical School of Chinese PLA, Beijing 100853, China.
  • Yang Y; Department of Pediatrics, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100037, China.
  • Wang Z; Department of Pediatrics, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100037, China.
  • Wang Q; Department of Pediatrics, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100037, China.
  • Liu W; Department of Pediatrics, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100037, China.
  • Zhang F; Department of Pediatrics, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100037, China.
  • Guan Q; Department of Pediatrics, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100037, China.
  • Wang X; Medical School of Chinese PLA, Beijing 100853, China.
  • Zang J; Department of Pediatrics, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100037, China.
  • Li X; Department of Pediatrics, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100037, China.
  • Liu H; Department of Pediatrics, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100037, China.
  • Yao R; Department of Pediatrics, the Sixth Medical Centre, Chinese PLA General Hospital, Beijing 100037, China.
  • Feng Z; Jiaen Genetics Laboratory, Beijing Jiaen Hospital, Beijing 100191, China.
  • Luan Z; Department of Neurobiology, Xuzhou Key Laboratory of Neurobiology, Xuzhou Medical University, Xuzhou, Jiangsu Province 221004, China.
iScience ; 26(5): 106647, 2023 May 19.
Article in En | MEDLINE | ID: mdl-37168574
Immune rejection can be reduced using immunosuppressants which are not viable for premature infants. However, desensitization can induce immune tolerance for premature infants because of underdeveloped immune system. The fetuses of Wistar rats at 15-17 days gestation were injected via hOPCs-1 into brain, muscles, and abdomen ex utero and then returned while the fetuses of control without injection. After 6 weeks of desensitization, the brain and muscles were transplanted with hOPCs-1, hNSCs-1, and hOPCs-2. After 10 and 34 weeks of desensitization, hOPCs-1 and hNSCs-1 in desensitized groups was higher than that in the control group while hOPCs-2 were rejected. Treg, CD4CD28, CD8CD28, and CD45RC between the desensitization and the control group differed significantly. Inflammatory cells in group with hOPCs-1 and hNSCs-1 was lower than that in the control group. hOPCs-1 can differentiate into myelin in desensitized groups. Wistar rats with desensitization developed immune tolerance to desensitized and transplanted cells.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: IScience Year: 2023 Document type: Article Affiliation country: China Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: IScience Year: 2023 Document type: Article Affiliation country: China Country of publication: United States