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A flexible wearable device coupled with injectable Fe3O4 nanoparticles for capturing circulating tumor cells and triggering their deaths.
Li, Ya; Liu, Xinyu; Zhang, Yingying; Wu, Ziyue; Ling, Wei; Zhang, Xinyu; Zhou, Mingxing; Onses, M Serdar; Zhou, Pan; Mao, Sui; Huo, Wenxing; Fan, Zhenzhen; Yang, Hong; Wang, Hanjie; Huang, Xian.
Affiliation
  • Li Y; Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Center of Flexible Wearable Technology, Institute of Flexible Electronic Technology of Tsinghua, 906 Yatai Road, Jiaxing, 314006, China.
  • Liu X; Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Center of Flexible Wearable Technology, Institute of Flexible Electronic Technology of Tsinghua, 906 Yatai Road, Jiaxing, 314006, China.
  • Zhang Y; School of Medical Imaging, Xuzhou Medical University, 209 Tongshan Road, Xuzhou, 221004, China.
  • Wu Z; Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Center of Flexible Wearable Technology, Institute of Flexible Electronic Technology of Tsinghua, 906 Yatai Road, Jiaxing, 314006, China.
  • Ling W; Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Center of Flexible Wearable Technology, Institute of Flexible Electronic Technology of Tsinghua, 906 Yatai Road, Jiaxing, 314006, China.
  • Zhang X; Department of Life Science, Tianjin University, 92 Weijin Road, Tianjin, 300072, China.
  • Zhou M; Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Center of Flexible Wearable Technology, Institute of Flexible Electronic Technology of Tsinghua, 906 Yatai Road, Jiaxing, 314006, China.
  • Onses MS; Department of Materials Science and Engineering, Erciyes University, Talas Yolu Melikgazi, Kayseri, 38039, Turkey.
  • Zhou P; Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Center of Flexible Wearable Technology, Institute of Flexible Electronic Technology of Tsinghua, 906 Yatai Road, Jiaxing, 314006, China.
  • Mao S; Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Center of Flexible Wearable Technology, Institute of Flexible Electronic Technology of Tsinghua, 906 Yatai Road, Jiaxing, 314006, China.
  • Huo W; Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Center of Flexible Wearable Technology, Institute of Flexible Electronic Technology of Tsinghua, 906 Yatai Road, Jiaxing, 314006, China.
  • Fan Z; Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China.
  • Yang H; The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Department of Pharmacology, School of Basic Medical Sciences, School of Biomedical Engineering, Intensive Care Unit, The Second Hospital, Tianjin Medical University, 22 Qixiangtai Road, Tianjin, 300070, C
  • Wang H; Department of Life Science, Tianjin University, 92 Weijin Road, Tianjin, 300072, China. Electronic address: wanghj@tju.edu.cn.
  • Huang X; Department of Biomedical Engineering, Tianjin University, 92 Weijin Road, Tianjin, 300072, China; Center of Flexible Wearable Technology, Institute of Flexible Electronic Technology of Tsinghua, 906 Yatai Road, Jiaxing, 314006, China; Institute of Wearable Technology and Bioelectronics, Qiantang Sci
Biosens Bioelectron ; 235: 115367, 2023 Sep 01.
Article in En | MEDLINE | ID: mdl-37187061
ABSTRACT
Elimination of circulating tumor cells (CTCs) in the blood can be an effective therapeutic approach to disrupt metastasis. Here, a strategy is proposed to implement flexible wearable electronics and injectable nanomaterials to disrupt the hematogenous transport of CTCs. A flexible device containing an origami magnetic membrane is used to attract Fe3O4@Au nanoparticles (NPs) that are surface modified with specific aptamers and intravenously injected into blood vessels, forming an invisible hand and fishing line/bait configuration to specifically capture CTCs through bonding with aptamers. Thereafter, thinned flexible AlGaAs LEDs in the device offer an average fluence of 15.75 mW mm-2 at a skin penetration depth of 1.5 mm, causing a rapid rise of temperature to 48 °C in the NPs and triggering CTC death in 10 min. The flexible device has been demonstrated for intravascular isolation and enrichment of CTCs with a capture efficiency of 72.31% after 10 cycles in a simulated blood circulation system based on a prosthetic upper limb. The fusion of nanomaterials and flexible electronics reveals an emerging field that utilizes wearable and flexible stimulators to activate biological effects offered by nanomaterials, leading to improved therapeutical effects and postoperative outcomes of diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biosensing Techniques / Nanostructures / Metal Nanoparticles / Neoplastic Cells, Circulating Limits: Humans Language: En Journal: Biosens Bioelectron Journal subject: BIOTECNOLOGIA Year: 2023 Document type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Biosensing Techniques / Nanostructures / Metal Nanoparticles / Neoplastic Cells, Circulating Limits: Humans Language: En Journal: Biosens Bioelectron Journal subject: BIOTECNOLOGIA Year: 2023 Document type: Article Affiliation country: China