Phenotyping mice with skin, hair, or nail abnormalities: A systematic approach and methodologies from simple to complex.
Vet Pathol
; 60(6): 829-842, 2023 11.
Article
in En
| MEDLINE
| ID: mdl-37191004
ABSTRACT
The skin and adnexa can be difficult to interpret because they change dramatically with the hair cycle throughout life. However, a variety of methods are commonly available to collect skin and perform assays that can be useful for figuring out morphological and molecular changes. This overview provides information on basic approaches to evaluate skin and its molecular phenotype, with references for more detail, and interpretation of results on the skin and adnexa in the mouse. These approaches range from mouse genetic nomenclature, setting up a cutaneous phenotyping study, skin grafts, hair follicle reconstitution, wax stripping, electron microscopy, and Köbner reaction to very specific approaches such as lipid and protein analyses on a large scale.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Nails, Malformed
Limits:
Animals
Language:
En
Journal:
Vet Pathol
Year:
2023
Document type:
Article