SQSTM1/P62 promotes lysophagy via formation of liquid-like condensates maintained by HSP27.

Gallagher, Elizabeth R; Holzbaur, Erika L F

Gallagher, Elizabeth R; Holzbaur, Erika L F.

Affiliation

Gallagher ER; Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Holzbaur ELF; Department of Physiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Autophagy ; 19(11): 3029-3030, 2023 11.

Article in En | MEDLINE | ID: mdl-37194327

ABSTRACT

ABSTRACT

ABBREVIATIONS SQSTM1/p62 Sequestosome-1; HSP27 Heat shock protein 27; LLPS liquid-liquid phase separation; iPSC induced pluripotent stem cell; PB1 Phox and Bem1p; FRAP fluorescence recovery after photo-bleaching; ATG autophagy-related; ALS amyotrophic lateral sclerosis.

Subject(s)

Amyotrophic Lateral Sclerosis; HSP27 Heat-Shock Proteins; Humans; Sequestosome-1 Protein/metabolism; HSP27 Heat-Shock Proteins/metabolism; Macroautophagy; Autophagy; Amyotrophic Lateral Sclerosis/metabolism

Key words

HSP27; Lysosomes; Sqstm1/P62; lysophagy; neurodegeneration; phase separation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: HSP27 Heat-Shock Proteins / Amyotrophic Lateral Sclerosis Limits: Humans Language: En Journal: Autophagy Year: 2023 Document type: Article Affiliation country: United States

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