Calcium-triggered DNA-mediated membrane fusion in synthetic cells.
bioRxiv
; 2023 Jun 02.
Article
in En
| MEDLINE
| ID: mdl-37205334
ABSTRACT
In cells, membrane fusion is mediated by SNARE proteins, whose activities are calcium-dependent. While several non-native membrane fusion mechanisms have been demonstrated, few can respond to external stimuli. Here, we develop a calcium-triggered DNA-mediated membrane fusion strategy where fusion is regulated using surface-bound PEG chains that are cleavable by the calcium-activated protease calpain-1.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
BioRxiv
Year:
2023
Document type:
Article
Affiliation country:
United States