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Genetic correlation, causal relationship, and shared loci between vitamin D and COVID-19: A genome-wide cross-trait analysis.
Qiu, Shizheng; Zheng, Keyang; Hu, Yang; Liu, Guiyou.
Affiliation
  • Qiu S; School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
  • Zheng K; School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.
  • Hu Y; School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
  • Liu G; Beijing Institute of Brain Disorders, Laboratory of Brain Disorders, Ministry of Science and Technology, Collaborative Innovation Center for Brain Disorders, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China.
J Med Virol ; 95(5): e28780, 2023 05.
Article in En | MEDLINE | ID: mdl-37212302
Observational studies have shown that vitamin D supplementation reduces the risk of COVID-19 infection, yet little is known about the shared genomic architectures between them. Leveraging large-scale genome-wide association study (GWAS) summary statistics, we investigated the genetic correlation and causal relationship between genetically determined vitamin D and COVID-19 using linkage disequilibrium score regression and Mendelian randomization (MR) analyses, and conducted a cross-trait GWAS meta-analysis to identify the overlapping susceptibility loci of them. We observed a significant genetic correlation between genetically predicted vitamin D and COVID-19 (rg = -0.143, p = 0.011), and the risk of COVID-19 infection would decrease by 6% for every 0.76 nmol L-1 increase of serum 25 hydroxyvitamin D (25OHD) concentrations in generalized MR (OR = 0.94, 95% CI: 0.89-0.99, p = 0.019). We identified rs4971066 (EFNA1) as a risk locus for the joint phenotype of vitamin D and COVID-19. In conclusion, genetically determined vitamin D is associated with COVID-19. Increased levels of serum 25OHD concentration may benefit the prevention and treatment of COVID-19.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genome-Wide Association Study / COVID-19 Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: J Med Virol Year: 2023 Document type: Article Affiliation country: China Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genome-Wide Association Study / COVID-19 Type of study: Clinical_trials / Observational_studies / Prognostic_studies / Systematic_reviews Limits: Humans Language: En Journal: J Med Virol Year: 2023 Document type: Article Affiliation country: China Country of publication: United States