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Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice.
Zhang, Jing; Sharma, Deepti; Dinabandhu, Aumreetam; Sanchez, Jaron; Applewhite, Brooks; Jee, Kathleen; Deshpande, Monika; Flores-Bellver, Miguel; Hu, Ming-Wen; Guo, Chuanyu; Salman, Shaima; Hwang, Yousang; Anders, Nicole M; Rudek, Michelle A; Qian, Jiang; Canto-Soler, M Valeria; Semenza, Gregg L; Montaner, Silvia; Sodhi, Akrit.
Affiliation
  • Zhang J; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Sharma D; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, Guangdong, China.
  • Dinabandhu A; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Sanchez J; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Applewhite B; Department of Oncology and Diagnostic Sciences, School of Dentistry, Greenebaum Comprehensive Cancer Center, University of Maryland, Baltimore, Maryland, USA.
  • Jee K; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Deshpande M; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Flores-Bellver M; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Hu MW; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Guo C; CellSight Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Salman S; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Hwang Y; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Anders NM; Armstrong Oxygen Biology Research Center; Vascular Program, Institute for Cell Engineering; Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, Biological Chemistry, and Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Rudek MA; Armstrong Oxygen Biology Research Center; Vascular Program, Institute for Cell Engineering; Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, Biological Chemistry, and Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Qian J; The Sidney Kimmel Comprehensive Cancer Center, Department of Oncology and the Division of Clinical Pharmacology at the School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Canto-Soler MV; The Sidney Kimmel Comprehensive Cancer Center, Department of Oncology and the Division of Clinical Pharmacology at the School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
  • Semenza GL; Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
  • Montaner S; CellSight Ocular Stem Cell and Regeneration Research Program, Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, Colorado, USA.
  • Sodhi A; Armstrong Oxygen Biology Research Center; Vascular Program, Institute for Cell Engineering; Departments of Pediatrics, Medicine, Oncology, Radiation Oncology, Biological Chemistry, and Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
J Clin Invest ; 133(13)2023 07 03.
Article in En | MEDLINE | ID: mdl-37227777
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Neovascularization / Diabetes Mellitus, Experimental / Diabetic Retinopathy Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Retinal Neovascularization / Diabetes Mellitus, Experimental / Diabetic Retinopathy Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2023 Document type: Article Affiliation country: United States Country of publication: United States