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Novel anemia therapies in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
Ku, Elaine; Del Vecchio, Lucia; Eckardt, Kai-Uwe; Haase, Volker H; Johansen, Kirsten L; Nangaku, Masaomi; Tangri, Navdeep; Waikar, Sushrut S; Wiecek, Andrzej; Cheung, Michael; Jadoul, Michel; Winkelmayer, Wolfgang C; Wheeler, David C.
Affiliation
  • Ku E; Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, California, USA; Division of Pediatric Nephrology, Department of Pediatrics, University of California San Francisco, San Francisco, California, USA; Department of Epidemiology and Biostatistics, Un
  • Del Vecchio L; Department of Nephrology and Dialysis, Sant'Anna Hospital, ASST Lariana, Como, Italy.
  • Eckardt KU; Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.
  • Haase VH; Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA; Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA; Program in Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee,
  • Johansen KL; Division of Nephrology, Hennepin Healthcare, Minneapolis, Minnesota, USA; Division of Nephrology, University of Minnesota, Minneapolis, Minnesota, USA.
  • Nangaku M; Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • Tangri N; Chronic Disease Innovation Centre, Seven Oaks General Hospital, Winnipeg, Manitoba, Canada; Department of Internal Medicine, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
  • Waikar SS; Section of Nephrology, Department of Medicine, Boston Medical Center and Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts, USA.
  • Wiecek A; Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, Katowice, Poland.
  • Cheung M; Kidney Disease: Improving Global Outcomes (KDIGO), Brussels, Belgium.
  • Jadoul M; Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium.
  • Winkelmayer WC; Selzman Institute for Kidney Health, Section of Nephrology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA.
  • Wheeler DC; Department of Renal Medicine, University College London, London, UK. Electronic address: d.wheeler@ucl.ac.uk.
Kidney Int ; 104(4): 655-680, 2023 10.
Article in En | MEDLINE | ID: mdl-37236424
Anemia is common in patients with chronic kidney disease and is associated with a high burden of morbidity and adverse clinical outcomes. In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline for the diagnosis and management of anemia in chronic kidney disease. Since then, new data from studies assessing established and emerging therapies for the treatment of anemia and iron deficiency have become available. Beginning in 2019, KDIGO planned 2 Controversies Conferences to review the new evidence and its potential impact on the management of anemia in clinical practice. Here, we report on the second of these conferences held virtually in December 2021, which focused on a new class of agents-the hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs). This report provides a review of the consensus points and controversies from this second conference and highlights areas that warrant prioritization for future research.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renal Insufficiency, Chronic / Prolyl-Hydroxylase Inhibitors / Anemia Type of study: Diagnostic_studies / Etiology_studies / Guideline Limits: Humans Language: En Journal: Kidney Int Year: 2023 Document type: Article Country of publication: United States
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Renal Insufficiency, Chronic / Prolyl-Hydroxylase Inhibitors / Anemia Type of study: Diagnostic_studies / Etiology_studies / Guideline Limits: Humans Language: En Journal: Kidney Int Year: 2023 Document type: Article Country of publication: United States