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A cross-sectional study of human papillomavirus genotype distribution and integration status in penile cancer among Chinese population.
Lang, Bin; Dong, Dirong; Zhao, Tong; Zhong, Ruolei; Qin, Huimin; Cao, Chen; Wang, Yuyan; Liu, Ting; Liang, Wenjia; Tian, Xun; Yan, Yongji; Hu, Zheng.
Affiliation
  • Lang B; Peking University Health Science Center - Macao Polytechnic University Nursing Academy, Macao Polytechnic University, Macao 999078, China. Electronic address: blang@mpu.edu.mo.
  • Dong D; Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Donghu 169th Road, Wuchang District, Wuhan, 430062, Hubei, China. Electronic address: dongdirong@znhospital.cn.
  • Zhao T; Academician Expert Workstation, Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China. Electronic address: zhaotong2023@foxmail.com.
  • Zhong R; Department of Hepatobiliary Surgery, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, 430014, China. Electronic address: 22502169@qq.com.
  • Qin H; Department of Obstetrics and Gynecology, Zhongnan Hospital of Wuhan University, Donghu 169th Road, Wuchang District, Wuhan, 430062, Hubei, China. Electronic address: 6349261@qq.com.
  • Cao C; Academician Expert Workstation, Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China. Electronic address: caochen@zxhospital.com.
  • Wang Y; Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510000, China. Electronic address: wangyy365@mail2.sysu.edu.cn.
  • Liu T; Academician Expert Workstation, Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China. Electronic address: tingl@whu.edu.cn.
  • Liang W; Academician Expert Workstation, Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China. Electronic address: lwjwhszxyy@sina.com.
  • Tian X; Academician Expert Workstation, Department of Obstetrics and Gynecology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430014, China. Electronic address: tianxun@zxhospital.com.
  • Yan Y; Department of Urology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100000, China. Electronic address: 7577yyj@163.com.
  • Hu Z; Department of Obstetrics and Gynecology, Women and Children's Hospital Affiliated to Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Department of Radiation a nd Medical Oncology Zhongnan Hospital of Wuhan University, Wuhan, 430071, China; Hubei Key Laboratory of Tumor Biological Behavi
Virology ; 584: 53-57, 2023 07.
Article in En | MEDLINE | ID: mdl-37244055
ABSTRACT
Human papillomavirus (HPV) has been recognized as an important risk factor in penile cancer. This study aimed to investigate the HPV subtypes and integration status in Chinese patients. Samples were collected from 103 penile cancer patients aged 24-90 years between 2013 and 2019. We found that HPV infection rate was 72.8%, with 28.0% integration. The aging patients were more susceptible to HPV (p = 0.009). HPV16 was the most frequent subtype observed (52/75) and exhibited the highest frequency of integration events, with 11 out of 30 single infection cases showing integration positive. The HPV integrations sites in the viral genome were not randomly distributed, the breakpoints were enriched in the E1 gene (p = 0.006) but relatively scarce in L1, E6 and E7. Our research might provide some clues how HPV leads to the progression of penile cancer.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penile Neoplasms / Oncogene Proteins, Viral / Papillomavirus Infections / Human Papillomavirus Viruses Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Humans / Male / Middle aged Language: En Journal: Virology Year: 2023 Document type: Article Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Penile Neoplasms / Oncogene Proteins, Viral / Papillomavirus Infections / Human Papillomavirus Viruses Type of study: Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Aged / Aged80 / Humans / Male / Middle aged Language: En Journal: Virology Year: 2023 Document type: Article Publication country: EEUU / ESTADOS UNIDOS / ESTADOS UNIDOS DA AMERICA / EUA / UNITED STATES / UNITED STATES OF AMERICA / US / USA