A cross-sectional study of human papillomavirus genotype distribution and integration status in penile cancer among Chinese population.
Virology
; 584: 53-57, 2023 07.
Article
in En
| MEDLINE
| ID: mdl-37244055
ABSTRACT
Human papillomavirus (HPV) has been recognized as an important risk factor in penile cancer. This study aimed to investigate the HPV subtypes and integration status in Chinese patients. Samples were collected from 103 penile cancer patients aged 24-90 years between 2013 and 2019. We found that HPV infection rate was 72.8%, with 28.0% integration. The aging patients were more susceptible to HPV (p = 0.009). HPV16 was the most frequent subtype observed (52/75) and exhibited the highest frequency of integration events, with 11 out of 30 single infection cases showing integration positive. The HPV integrations sites in the viral genome were not randomly distributed, the breakpoints were enriched in the E1 gene (p = 0.006) but relatively scarce in L1, E6 and E7. Our research might provide some clues how HPV leads to the progression of penile cancer.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Penile Neoplasms
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Oncogene Proteins, Viral
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Papillomavirus Infections
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Human Papillomavirus Viruses
Type of study:
Observational_studies
/
Prevalence_studies
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Risk_factors_studies
Limits:
Adult
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Aged
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Aged80
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Humans
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Male
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Middle aged
Language:
En
Journal:
Virology
Year:
2023
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
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ESTADOS UNIDOS DA AMERICA
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EUA
/
UNITED STATES
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UNITED STATES OF AMERICA
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US
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USA