In-silico method for elucidation of prodigiosin as PARP-1 inhibitor a prime target of Triple-negative breast cancer.

Sundararajan, Priya; Dharmaraj Rajaselvi, Darjily; Vivekananthan, Suseela; Priya Ramasamy, Shanmuga

Sundararajan, Priya; Dharmaraj Rajaselvi, Darjily; Vivekananthan, Suseela; Priya Ramasamy, Shanmuga.

Affiliation

Sundararajan P; Department of Microbiology, PSG College of Arts & Science, Coimbatore 641014, Tamil Nadu, India.
Dharmaraj Rajaselvi D; Department of Microbiology, PSG College of Arts & Science, Coimbatore 641014, Tamil Nadu, India.
Vivekananthan S; Department of Biochemistry, PSG College of Arts & Science, Coimbatore 641014, Tamil Nadu, India.
Priya Ramasamy S; Department of Microbiology, PSG College of Arts & Science, Coimbatore 641014, Tamil Nadu, India. Electronic address: priyajasper@gmail.com.

Bioorg Chem ; 138: 106618, 2023 09.

Article in En | MEDLINE | ID: mdl-37244231

Subject(s)

Antineoplastic Agents; Triple Negative Breast Neoplasms; Humans; Poly(ADP-ribose) Polymerase Inhibitors/pharmacology; Poly(ADP-ribose) Polymerase Inhibitors/therapeutic use; Poly (ADP-Ribose) Polymerase-1; Triple Negative Breast Neoplasms/metabolism; Prodigiosin/pharmacology; Prodigiosin/therapeutic use; Molecular Docking Simulation; Cell Line, Tumor; Antineoplastic Agents/chemistry

Key words

Breast cancer; MD simulation; Molecular docking; PARP-1; Pharmacokinetics; TNBC

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Triple Negative Breast Neoplasms / Antineoplastic Agents Type of study: Prognostic_studies Limits: Humans Language: En Journal: Bioorg Chem Year: 2023 Document type: Article Affiliation country: India Country of publication: United States

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