The long non-coding RNA ZFAS1 promotes colorectal cancer progression via miR200b/ZEB1 axis.
Pathol Res Pract
; 247: 154567, 2023 Jul.
Article
in En
| MEDLINE
| ID: mdl-37245266
ABSTRACT
BACKGROUND:
Colorectal cancer (CRC) is a common tumor worldwide. CRC is influenced by several types of miRNAs and long non-coding RNAs. This study aims to evaluate the correlation of lncRNA ZFAS1/ miR200b/ ZEB1 protein with presence of CRC.METHODS:
Quantitative real-time polymerase chain reaction was used to measure serum expression of lncRNA ZFAS1 and microRNA-200b in 60 CRC patients and 28 control subjects. ZEB1 protein in serum was measured by ELISA.RESULTS:
Lnc ZFAS1 and ZEB1 were up-regulated in CRC patients in compare to control subjects while miR-200b was down-regulated. There was a linear correlation between ZAFS1 expression and miR-200b and ZEB1 in CRC.CONCLUSION:
ZFAS1 is a key player of CRC progression and could be a potential therapeutic target by sponging miR-200b. In-addition the association between ZFAS1, miR-200b and ZEB1 highlights their potential value as a novel diagnostic biomarker in human CRC.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Colorectal Neoplasms
/
MicroRNAs
/
RNA, Long Noncoding
Limits:
Humans
Language:
En
Journal:
Pathol Res Pract
Year:
2023
Document type:
Article
Affiliation country:
Egypt