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Isoliquiritigenin inhibits circ0030018 to suppress glioma tumorigenesis via the miR-1236/HER2 signaling pathway.
Liu, Aiqun; Jiang, Baohong; Song, Cailu; Zhong, Qizhi; Mo, Yufan; Yang, Ruiqin; Chen, Ciyu; Peng, Cheng; Peng, Fu; Tang, Hailin.
Affiliation
  • Liu A; Department of Neurology School of Clinical Medicine  the First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou China.
  • Jiang B; Department of Pharmacy, the First Affiliated Hospital, Hengyang Medical School University of South China Hengyang China.
  • Song C; State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center Guangzhou China.
  • Zhong Q; Department of Neurology School of Clinical Medicine  the First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou China.
  • Mo Y; Department of Neurology School of Clinical Medicine  the First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou China.
  • Yang R; Department of Neurology School of Clinical Medicine  the First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou China.
  • Chen C; Department of Neurology School of Clinical Medicine  the First Affiliated Hospital of Guangdong Pharmaceutical University Guangzhou China.
  • Peng C; State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine Chengdu China.
  • Peng F; West China School of Pharmacy Sichuan University Chengdu China.
  • Tang H; State Key Laboratory of Oncology in South China Sun Yat-sen University Cancer Center Guangzhou China.
MedComm (2020) ; 4(3): e282, 2023 Jun.
Article in En | MEDLINE | ID: mdl-37250146
In the central nervous system diseases, glioma is one of the most common malignancies around the world. Despite the recent improvements in therapies for glioma, the prognosis of some high-risk glioma remains poor. In glioma, isoliquiritigenin (ISL) is reported to have antioxidative and antitumor activities. However, the potential mechanisms between ISL and circle RNAs (circRNAs) in the glioma tumorigenesis process have not yet been reported. Here, we treated glioma cells with ISL, and circRNA expression levels were detected. Circ0030018 was found significantly downregulated by ISL. Therefore, we explored circ0030018 expression profiles and functions in glioma, finding that circ0030018 was evidently overexpressed in glioma cell lines. Colony formation, CCK-8, and transwell assay made clear that circ0030018 silencing dramatically cut down glioma growth and invasion. Moreover, ROS level was detected to find that circ0030018 silence remarkably enhanced cell oxidative stress in glioma. Mechanism studies were conducted to investigate the underlying basis of circ0030018 function in glioma, unveiling that circ0030018 realized its functions partially through the miR-1236/HER2 signaling in glioma. In conclusion, our study investigated the roles and mechanisms of the ISL on the circ0030018/miR-1236/HER2 pathway in glioma tumorigenesis and progression. Circ0030018 could act as the prospective biologic signature or therapeutic target for glioma.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: MedComm (2020) Year: 2023 Document type: Article Country of publication: China

Full text: 1 Collection: 01-internacional Database: MEDLINE Type of study: Prognostic_studies Language: En Journal: MedComm (2020) Year: 2023 Document type: Article Country of publication: China