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Simultaneous multicolor imaging of lymph node chains using hydroporphyrin-doped near-infrared-emitting polymer dots.
Kato, Takuya; Riahin, Connor; Furusawa, Aki; Fukushima, Hiroshi; Wakiyama, Hiroaki; Okuyama, Shuhei; Takao, Seiichiro; Choyke, Peter L; Ptaszek, Marcin; Rosenzweig, Zeev; Kobayashi, Hisataka.
Affiliation
  • Kato T; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1088, USA.
  • Riahin C; Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.
  • Furusawa A; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1088, USA.
  • Fukushima H; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1088, USA.
  • Wakiyama H; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1088, USA.
  • Okuyama S; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1088, USA.
  • Takao S; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1088, USA.
  • Choyke PL; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1088, USA.
  • Ptaszek M; Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.
  • Rosenzweig Z; Department of Chemistry & Biochemistry, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA.
  • Kobayashi H; Molecular Imaging Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892-1088, USA.
Nanomedicine (Lond) ; 18(8): 659-666, 2023 04.
Article in En | MEDLINE | ID: mdl-37254845
ABSTRACT

Aim:

Evaluation of lymphatic drainage can be challenging to differentiate between separate drainage basins because only one 'color' is typically employed in sentinel node studies. This study aimed to test the feasibility of multicolor in vivo lymphangiography using newly developed organic polymer dots. Materials &

methods:

Biocompatible, purely organic, hydroporphyrin-doped near-infrared-emitting polymer dots were developed and evaluated for in vivo multicolor imaging in mouse lymph nodes. Results &

conclusion:

The authors demonstrated successful multicolor in vivo fluorescence lymphangiography using polymer dots, each tuned to a different emission spectrum. This allows minimally invasive visualization of at least four separate lymphatic drainage basins using fluorescent nanoparticles, which have the potential for clinical translation.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sentinel Lymph Node Biopsy / Quantum Dots Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Nanomedicine (Lond) Year: 2023 Document type: Article Affiliation country: United States
Fulltext
Add to My VHL
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sentinel Lymph Node Biopsy / Quantum Dots Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Nanomedicine (Lond) Year: 2023 Document type: Article Affiliation country: United States