Elevated Expression of ADAM10 Induced by HPV E6 Influences the Prognosis of Cervical Cancer.
Genet Test Mol Biomarkers
; 27(5): 165-171, 2023 May.
Article
in En
| MEDLINE
| ID: mdl-37257180
ABSTRACT
Objective:
To explore the abnormal expression of ADAM10, its cause, and its clinical value in the prognosis of cervical lesions.Methods:
The abnormal expression of ADAM10 was explored using the Gene Expression Profiling Interactive Analysis database, and the abnormal expression in cervical lesions was verified using immunohistochemistry (IHC). The transfection effect of shRNA was evaluated using real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The expression of ADAM10 in cells was analyzed using western blotting.Results:
ADAM10 was highly expressed in multiple cancers. As the disease progressed, the expression of ADAM10 gradually increased (p < 0.05). Patients with higher expression of ADAM10 had poorer survival outcomes than those with lower expression levels (p < 0.05). The expression levels of ADAM10 decreased after expression levels of E6 was inhibited.Conclusion:
ADAM10 is highly expressed in cervical cancer; the higher the expression levels, the worse the survival outcome. HPV E6 is the critical driver of the elevated expression of ADAM10 in cervical cancer.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Uterine Cervical Neoplasms
/
Oncogene Proteins, Viral
/
Papillomavirus Infections
Type of study:
Prognostic_studies
Limits:
Female
/
Humans
Language:
En
Journal:
Genet Test Mol Biomarkers
Journal subject:
BIOLOGIA MOLECULAR
/
GENETICA
Year:
2023
Document type:
Article
Affiliation country:
China