Molecular epidemiology of Canine circovirus in domestic dogs and wildlife in Namibia, Africa.
Infect Genet Evol
; 112: 105458, 2023 08.
Article
in En
| MEDLINE
| ID: mdl-37257803
ABSTRACT
Canine circovirus (CanineCV) is a DNA virus affecting domestic dogs and other wild carnivore species. Despite the potential implications for dogs' health and wildlife conservation, data on CanineCV presence, epidemiology and genetic features from Africa is still poor. In the present study, biological specimens collected between 2020 and 2022 from a total of 32 jackals and 575 domestic dogs were tested for the presence of CanineCV DNA to evaluate its frequency. Furthermore, sequencing was conducted on positive samples to characterize the strains and compare them with publicly available sequences through phylogenetic analysis. A high CanineCV prevalence was observed both in jackals (43.75%; 95 CI 28.17% - 60.67%) and domestic dogs (27.13%; 95 CI 23.66% - 30.91%). All aside from one Namibian strain formed an independent clade, suggestive of extremely rare introduction events, followed by local persistence, circulation, and evolution. Remarkably, different recombination events were observed involving strains from both jackals and domestic dogs, which testify to the likely strain exchange between these populations. Distinctive amino acid residues were also observed in jackals. The limitations of the considered host populations however prevent a definitive conclusion on host adaptation, biological, and clinical features. Further studies should be performed to expand our current knowledge of the CanineCV disease scenario in Namibia, other African regions, and associated host species in Africa.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Circovirus
/
Dog Diseases
Type of study:
Risk_factors_studies
/
Screening_studies
Limits:
Animals
Country/Region as subject:
Africa
Language:
En
Journal:
Infect Genet Evol
Journal subject:
BIOLOGIA
/
DOENCAS TRANSMISSIVEIS
/
GENETICA
Year:
2023
Document type:
Article
Affiliation country:
Namibia