Differential molecular pathway expression according to chemotherapeutic response in ovarian clear cell carcinoma.
BMC Womens Health
; 23(1): 298, 2023 06 03.
Article
in En
| MEDLINE
| ID: mdl-37270486
ABSTRACT
OBJECTIVE:
Ovarian clear cell carcinoma (OCCC) is a distinct entity from epithelial ovarian cancer. The prognosis of advanced and recurrent disease is very poor due to resistance to chemotherapeutic agents. Our aim was to explore the molecular alterations among OCCC patients with different chemotherapeutic responses and to obtain insights into potential biomarkers.METHODS:
Twenty-four OCCC patients were included in this study. The patients were divided into two groups based on the relapse time after the first-line platinum-based chemotherapy the platinum-sensitive group (PS) and the platinum-resistant group (PR). Gene expression profiling was performed using NanoString nCounter PanCancer Pathways Panel.RESULTS:
Gene expression analysis comparing PR vs. PS identified 32 differentially expressed genes 17 upregulated genes and 15 downregulated genes. Most of these genes are involved in the PI3K, MAPK and Cell Cycle-Apoptosis pathways. In particular, eight genes are involved in two or all three pathways.CONCLUSION:
The dysregulated genes in the PI3K, MAPK, and Cell Cycle-Apoptosis pathways identified and postulated mechanisms could help to probe biomarkers of OCCC platinum sensitivity, providing a research basis for further exploration of targeted therapy.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
Limits:
Female
/
Humans
Language:
En
Journal:
BMC Womens Health
Journal subject:
SAUDE DA MULHER
Year:
2023
Document type:
Article
Affiliation country:
China