The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts.
Turk Kardiyol Dern Ars
; 51(4): 235-240, 2023 06.
Article
in En
| MEDLINE
| ID: mdl-37272158
ABSTRACT
OBJECTIVE:
Curcumin is a bioactive compound that has well-known pharmacological activities. Numerous studies have shown that curcumin provides potential cardiovascular beneï¬ts through a variety of mechanisms.The present study aims to discuss diï¬erent concentrations of curcumin's impact on mechanical functions and cardiac contractility in isolated perfused rat hearts.METHODS:
The hearts were isolated under sodium thiopental (50 mg/kg) anesthesia and perfused with a modiï¬ed Krebs-Henseleit solution (mK-Hs). After stabilization, curcumin was applied in concentrations of 0.1, 1, and 10 µM. In isolated rat hearts, indexes of + dP / dt max, LVDP, MAP, and LVEDP were evaluated for cardiac contractility and ventricular function.RESULTS:
All curcumin concentrations reduced +dP/dtmax and LVDP. Ten µM curcumin also signiï¬cantly decreased heart rate. Curcumin (1 and 10 µM) increased LVEDP and reduced MAP amplitude with a concomitant increase in MAP duration. Curcumin at all concentrations did not aï¬ect dMAPdtmax and dMAPdtmin.CONCLUSION:
Our results might suggest that curcumin at higher concentrations (≥ 1 µM) increases LVEDP with a negative chronotropic eï¬ect and decreases MAP amplitude with an increase in MAP duration. There is suï¬cient evidence from this study that Curcumin possesses an adverse inotropic action. Diï¬erent disease models should support the pathophysiological role of Curcumin on cardiac contraction.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Curcumin
Limits:
Animals
/
Humans
Language:
En
Journal:
Turk Kardiyol Dern Ars
Journal subject:
CARDIOLOGIA
Year:
2023
Document type:
Article