Reduction in Rubicon by cigarette smoke is associated with impaired phagocytosis and occurs through lysosomal degradation pathway.

Asare, Patrick F; Hurtado, Plinio R; Tran, Hai B; Perkins, Griffith B; Roscioli, Eugene; Hodge, Sandra

Asare, Patrick F; Hurtado, Plinio R; Tran, Hai B; Perkins, Griffith B; Roscioli, Eugene; Hodge, Sandra.

Affiliation

Asare PF; Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia. pharmapf@yahoo.com.
Hurtado PR; Department of Thoracic Medicine, Faculty of Health and Medical Science, The University of Adelaide, Adelaide, Australia. pharmapf@yahoo.com.
Tran HB; School of Medicine, University of Adelaide, Adelaide, Australia.
Perkins GB; Department of Renal Medicine, Royal Adelaide Hospital, Adelaide, Australia.
Roscioli E; School of Medicine, University of Adelaide, Adelaide, Australia.
Hodge S; Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia.

Clin Exp Med ; 23(7): 4041-4055, 2023 Nov.

Article in En | MEDLINE | ID: mdl-37310658

Subject(s)

Cigarette Smoking; Pulmonary Disease, Chronic Obstructive; Humans; Cigarette Smoking/adverse effects; Phagocytosis; Macrophages/metabolism; Lysosomes/metabolism

Key words

Autophagy; Inflammation; LC3-associated phagocytosis (LAP); Phagocytosis; Rubicon

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pulmonary Disease, Chronic Obstructive / Cigarette Smoking Type of study: Risk_factors_studies Limits: Humans Language: En Journal: Clin Exp Med Journal subject: MEDICINA Year: 2023 Document type: Article Affiliation country: Australia Country of publication: Italy

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