The intersection of undernutrition, microbiome, and child development in the first years of life.
Nat Commun
; 14(1): 3554, 2023 06 15.
Article
in En
| MEDLINE
| ID: mdl-37322020
ABSTRACT
Undernutrition affects about one out of five children worldwide. It is associated with impaired growth, neurodevelopment deficits, and increased infectious morbidity and mortality. Undernutrition, however, cannot be solely attributed to a lack of food or nutrient deficiency but rather results from a complex mix of biological and environmental factors. Recent research has shown that the gut microbiome is intimately involved in the metabolism of dietary components, in growth, in the training of the immune system, and in healthy development. In this review, we look at these features in the first three years of life, which is a critical window for both microbiome establishment and maturation and child development. We also discuss the potential of the microbiome in undernutrition interventions, which could increase efficacy and improve child health outcomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Malnutrition
/
Microbiota
/
Gastrointestinal Microbiome
Aspects:
Determinantes_sociais_saude
Limits:
Child
/
Humans
Language:
En
Journal:
Nat Commun
Journal subject:
BIOLOGIA
/
CIENCIA
Year:
2023
Document type:
Article
Affiliation country:
Italy