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Unusual clinical presentations of plasma cell mucositis involving oral mucosa: Presentation of 2 cases and review of the literature.
Gilligan, Gerardo; Panico, René; Garola, Federico; Jara, René; Villarroel-Dorrego, Mariana; Martinez, Benjamín.
Affiliation
  • Gilligan G; Oral Medicine Department, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina. Electronic address: ggilligan@unc.edu.ar.
  • Panico R; Oral Medicine Department, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
  • Garola F; Oral Medicine Department, Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
  • Jara R; Oral Pathology Service, Universidad Mayor de Chile, Santiago de Chile, Chile.
  • Villarroel-Dorrego M; Oral Medicine and Pathology Department, Universidad Central de Venezuela, Caracas, Venezuela.
  • Martinez B; Oral Pathology Service, Universidad Mayor de Chile, Santiago de Chile, Chile.
Article in En | MEDLINE | ID: mdl-37328328
OBJECTIVE: Plasma cell mucositis (PCM) is a non-neoplastic plasma cell disorder of the upper aerodigestive tract with a high impact on life quality. Less than 70 cases were reported in the literature. The objective of this study was to report 2 cases of PCM. A concise review of the literature is also presented. STUDY DESIGN: Two cases of PCM that presented during the COVID-19 quarantine are reported. The inclusion criteria for the literature review were English-indexed case reports of the last 20 years. RESULTS: Cases were treated with meprednisone. As mechanical trauma was proposed as a triggering factor, its control was also considered. Patients were followed with no relapses. There were 29 studies included. The mean age was 57 years, with a male predominance, different clinical phenotypes, and intensely erythematous mucosa as a classical finding. The most frequent site was the lip, followed by the buccal mucosa. The final diagnosis is clinicopathologic. CD138 expression is a hallmark of plasma cells, frequently aiding PCM diagnosis. Plasma cell mucositis treatment is mostly symptomatic, and several therapeutic modalities have been mostly unsuccessful. CONCLUSIONS: Diagnosing plasma cell mucositis becomes challenging as many lesions may mimic other conditions. Consequently, in these cases, the diagnostic process should gather clinical, histopathologic, and immunohistochemical data.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mucositis / COVID-19 Limits: Female / Humans / Male Language: En Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Year: 2023 Document type: Article Country of publication: United States

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Mucositis / COVID-19 Limits: Female / Humans / Male Language: En Journal: Oral Surg Oral Med Oral Pathol Oral Radiol Year: 2023 Document type: Article Country of publication: United States