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SARS-CoV-2 targets the liver and manipulates glucose metabolism.
Pirola, Carlos J; Sookoian, Silvia.
Affiliation
  • Pirola CJ; Systems Biology of Complex Diseases, Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS), Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. Electronic address: pirola.carlos@conicet.gov.ar.
  • Sookoian S; Clinical and Molecular Hepatology, Centro de Altos Estudios en Ciencias Humanas y de la Salud (CAECIHS), Universidad Abierta Interamericana, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina; Maimonides University, Buenos Aires, Argentina. Electronic address: ssookoian@intramed.net.
Trends Mol Med ; 29(9): 681-683, 2023 09.
Article in En | MEDLINE | ID: mdl-37330366
ABSTRACT
A recent publication by Barreto and colleagues showed that SARS-CoV-2 directly triggers hyperglycemia by infecting hepatocytes and inducing phosphoenolpyruvate carboxykinase (PEPCK)-dependent gluconeogenesis. Here, we discuss the biological importance of these findings, including the hepatic tropism of SARS-CoV-2. We also comment on the clinical implications of the bidirectional connection between COVID-19 and noncommunicable diseases.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Language: En Journal: Trends Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2023 Document type: Article
Fulltext
Add to My VHL
Print
XML
PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Limits: Humans Language: En Journal: Trends Mol Med Journal subject: BIOLOGIA MOLECULAR Year: 2023 Document type: Article