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Two new anti-inflammatory trachylobane diterpenoids from Euphorbia atoto.
Zhao, Huan; Duan, Rui-Jun; Kong, Chui-Hao; Dai, Hao-Fu; Mei, Wen-Li; Xu, Feng-Qing; Huang, Sheng-Zhuo.
Affiliation
  • Zhao H; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Duan RJ; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
  • Kong CH; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Dai HF; Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Mei WL; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
  • Xu FQ; Key Laboratory of Research and Development of Natural Product from Li Folk Medicine of Hainan Province, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
  • Huang SZ; Hainan Institute for Tropical Agricultural Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
J Asian Nat Prod Res ; 26(3): 313-319, 2024 Mar.
Article in En | MEDLINE | ID: mdl-37342029
ABSTRACT
Two new rare trachylobane euphoratones A-B (1-2), together with five known diterpenoids (compounds 3-7), were isolated from the aerial parts of Euphorbia atoto. Their structures were unambiguously elucidated through HRESIMS, 1D and 2D NMR spectral analysis. Compounds 1, 3, 4 and 7 showed weak anti-inflammatory activities (IC50 77.49 ± 6.34, 41.61 ± 14.49, 16.00 ± 1.71 and 33.41 ± 4.52 µM, respectively), compared to the positive control quercetin (IC50 15.23 ± 0.65 µM).
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Euphorbia / Diterpenes Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2024 Document type: Article Affiliation country: China
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Euphorbia / Diterpenes Language: En Journal: J Asian Nat Prod Res Journal subject: BOTANICA / QUIMICA Year: 2024 Document type: Article Affiliation country: China