Reduced Plasma BDNF Levels in Normal Tension Glaucoma Compared to Open Angle Glaucoma.
J Glaucoma
; 32(9): 734-737, 2023 09 01.
Article
in En
| MEDLINE
| ID: mdl-37343190
ABSTRACT
PRCIS The study suggests that a low level of systemic BDNF may contribute to the pathogenesis of glaucoma in an IOP-independent manner. AIMS:
To evaluate differences in systemic brain-derived neurotrophic factor (BDNF) levels between primary open angle glaucoma (POAG) patients and normal tension glaucoma (NTG) patients.METHODS:
This study collected blood samples from 260 NTG patients, 220 age-matched POAG patients, and 120 age-matched cataract patients (as controls). BDNF levels were measured with an antibody-conjugated bead assay system (Luminex).RESULTS:
We found that plasma BDNF levels in the NTG group were significantly lower than in the POAG and cataract control groups. There was no significant difference between the POAG and cataract groups.CONCLUSION:
This result suggests that a low level of systemic BDNF may contribute to the pathogenesis of glaucoma in an IOP-independent manner.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Glaucoma, Open-Angle
/
Low Tension Glaucoma
Type of study:
Diagnostic_studies
Limits:
Humans
Language:
En
Journal:
J Glaucoma
Journal subject:
OFTALMOLOGIA
Year:
2023
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA