Angiotensin Receptor-Neprilysin Inhibitor Therapy and Cardiac Remodeling in Heart Failure: Consensus Statement from India.
J Assoc Physicians India
; 71(4): 11-12, 2023 Apr.
Article
in En
| MEDLINE
| ID: mdl-37355795
ABSTRACT
Adverse cardiac remodeling refers to progressive structural and functional modifications in the heart because of increased wall stress in the myocardium, loss of viable myocardium, and neurohormonal stimulation. The guideline-directed medical therapy for Heart failure (HF) includes Angiotensin receptor-neprilysin inhibitor (ARNI) (sacubitril/valsartan), ß-blockers, sodium-glucose co-transporter 2 (SGLT2) inhibitors, and mineralocorticoid receptor antagonists (MRA). ARNI is under-prescribed in India despite its attractive safety and efficacy profile. Therefore, the consensus discusses objectives and topics related to ARNI in the management of cardiac remodeling, and experts shared their views on the early timely intervention of effective dosage of ARNI to improve the diagnosis and enhance mortality and morbidity benefits in cardiac reverse remodeling (CRR).
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Neprilysin
/
Heart Failure
Type of study:
Diagnostic_studies
/
Guideline
Limits:
Humans
Language:
En
Journal:
J Assoc Physicians India
Year:
2023
Document type:
Article