Occipital Amyloid Deposition Is Associated with Rapid Cognitive Decline in the Alzheimer's Disease Continuum.
J Alzheimers Dis
; 94(3): 1133-1144, 2023.
Article
in En
| MEDLINE
| ID: mdl-37355901
ABSTRACT
BACKGROUND:
Clinical significance of additional occipital amyloid-ß (Aß) plaques in Alzheimer's disease (AD) remains unclear.OBJECTIVE:
In this study, we investigated the effect of regional Aß deposition on cognition in patients on the AD continuum, especially in the occipital region.METHODS:
We retrospectively reviewed the medical record of 208 patients with AD across the cognitive continuum (non-dementia and dementia). Multivariable linear regression analyses were performed to determine the effect of regional Aß deposition on cognitive function. A linear mixed model was used to assess the effect of regional deposition on longitudinal changes in Mini-Mental State Examination (MMSE) scores. Additionally, the patients were dichotomized according to the occipital-to-global Aß deposition ratio (ratio ≤1, Aß-OCC- group; ratio >1, Aß-OCC+ group), and the same statistical analyses were applied for between-group comparisons.RESULTS:
Regional Aß burden itself was not associated with baseline cognitive function. In terms of Aß-OCC group effect, the Aß-OCC+ group exhibited a poorer cognitive performance on language function compared to the Aß-OCC- group. High Aß retention in each region was associated with a rapid decline in MMSE scores, only in the dementia subgroup. Additionally, Aß-OCC+ individuals exhibited a faster annual decline in MMSE scores than Aß-OCC- individuals in the non-dementia subgroup (ß=â-0.77, standard error [SE]â=â0.31, pâ=â0.013).CONCLUSION:
The present study demonstrated that additional occipital Aß deposition was associated with poor baseline language function and rapid cognitive deterioration in patients on the AD continuum.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alzheimer Disease
/
Cognitive Dysfunction
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
J Alzheimers Dis
Journal subject:
GERIATRIA
/
NEUROLOGIA
Year:
2023
Document type:
Article
Affiliation country:
South Korea