Current screening, design, and delivery approaches to address low permeability of chemically synthesized modalities in drug discovery and early clinical development.

Yang, Wenzhan; Lipert, Maya; Nofsinger, Rebecca

Yang, Wenzhan; Lipert, Maya; Nofsinger, Rebecca.

Affiliation

Yang W; Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Boston, USA. Electronic address: Wenzhan.yang@astrazeneca.com.
Lipert M; Molecular Profiling and Drug Delivery, Small Molecule CMC Development, AbbVie, Inc., North Chicago, IL, USA.
Nofsinger R; ADME & Discovery Toxicology, Merck & Co., Inc., West Point, PA, USA.

Drug Discov Today ; 28(9): 103685, 2023 09.

Article in En | MEDLINE | ID: mdl-37356613

Subject(s)

Drug Delivery Systems; Drug Discovery; Drug Discovery/methods; Pharmaceutical Preparations/chemistry; Permeability; Technology

Key words

drug delivery; permeability; permeation enhancer; prodrug, chemical design

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Delivery Systems / Drug Discovery Type of study: Diagnostic_studies / Screening_studies Language: En Journal: Drug Discov Today Journal subject: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Year: 2023 Document type: Article Country of publication: United kingdom

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