[Incidence and clinical characteristics of engraftment syndrome after syngeneic hematopoietic stem cell transplantation in patients with hematological diseases].
Zhonghua Xue Ye Xue Za Zhi
; 44(4): 289-294, 2023 Apr 14.
Article
in Zh
| MEDLINE
| ID: mdl-37356997
ABSTRACT
Objective:
To explore the incidence and clinical characteristics of engraftment syndrome (ES) after syngeneic hematopoietic stem cell transplantation (syn-HSCT) in patients with hematological diseases.Methods:
The clinical data of 21 patients who received syn-HSCT at People's Hospital of Peking University from January 1994 to May 2018 were retrospectively analyzed.Results:
Seven (33.3% ) of 21 patients developed ES. The onset of ES symptoms occurred at a median of 8 (range 5-13) days after HSCT, and the diagnosis of ES occurred at a median of 10 (range 7-14) days after HSCT. Steroids were administered immediately after the diagnosis of ES, the median time of symptom continuance was 2 (range 1-5) days, and all patients showed complete resolution of ES symptoms. In the multivariate analysis, patients with acute myeloid leukemia and faster neutrophil reconstitution were the risk factors for ES (HR=15.298, 95% CI 1.486-157.501, P=0.022, and HR=17.459, 95% CI 1.776-171.687, P=0.014) . Meanwhile, there was no significant difference in the overall survival and disease-free survival between patients with ES and those without ES.Conclusion:
A high incidence of ES was observed in syn-HSCT recipients. Moreover, the prognosis of ES was excellent.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hematopoietic Stem Cell Transplantation
/
Graft vs Host Disease
/
Hematologic Diseases
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Zh
Journal:
Zhonghua Xue Ye Xue Za Zhi
Year:
2023
Document type:
Article
Affiliation country:
China